UNIVERSITY OF HOUSTON – DOWNTOWN

 

ENGR 4310 - INDUSTRIAL HYGIENE INSTRUMENTATION

 

LECTURE NOTE OUTLINE – CHAPTER 6

 

WEEK 3

 

I.                    Definition

A.                 Toxicology

B.                 IH Perspective

C.                 Toxicity vs. Hazard

D.                 IH Perspective

E.                  Toxicity

F.                  Hazard

G.                 Local vs. Systemic

 

II.                 Routes of Exposure

A.                 Inhalation

B.                 Skin Absorption

C.                 Ingestion

D.                 Injection

 

III.               Dose-Response Relationship

A.                 Dose-Response as C x T

B.                 Threshold vs. No-Effect Level

C.                 Toxicity – Chemical substance; Type and level of exposure; and fate

D.                 No Observable Effect Level (NOEL)

E.                  Lethal Dose (LD50)

F.                  Slope of Dose Response Curve

G.                 Lethal Concentration (LD)

H.                 Responses

I.                    Acute vs. Chronic


 

IV.              Effects of Exposure

A.                 Irritation

B.                 Allergens

C.                 Simple Asphyxiants

D.                 Chemical Asphyxiants

E.                  Organ-Specific Effects

1.                  CNS

2.                  Cardiac

3.                  Neural

4.                  Pulmonary

5.                  Carcinogenesis

6.                  Mutagenesis

7.                  Reproductive Toxicity

8.                  Teratogens

 

V.                 Workplace Standards

A.                 Chemical Analogy

B.                 In-Vitro Testing

C.                 Animal Experimentation

1.                  Exposure Standards

2.                  Screening Procedures

3.                  Problem Areas

D.                 Human Epidemiological Data

 

VI.              Federal Regulations

A.                 OSHAct

B.                 TOCA

C.                 NIOSH/OSHA Standards

 

VII.            Others Technical Guidelines

1.                  TLVs

2.                  TWAs

3.                  Ceiling Values

4.                  Mixtures

5.                  Carcinogens

6.                  Physical Factors

7.                  Unlisted Substances

8.                  Basic Data

9.                  Documentation

10.              BEIs

 

VIII.         Sources of Toxicological Information

A.                 MSDS

B.                 Other Resources